Family history of cancer is a strong risk factor for many cancers. Whilst very significant advances have been made in our understanding of common genetic variations contributing to cancer risk, the genetic factors contributing to the inherited portion of cancer risk and those factors influencing disease course remain poorly understood. Current opinion is that the study of families with multiple cases of inherited disease will be a fruitful, alternative approach to gene discovery in human complex disease. This project aims to identify those genetic factors contributing to familial cancer risk and disease course utilising the Tasmanian Familial Cancer Genetics Resources established at the Menzies Research Institute Tasmania.
Inherited determinants of Cancer Aetiology
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